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imSAVAR Workshop: Mapping Inflammation – Towards Predictive AOPs for Immune-Related Adverse Outcomes

Event Details

Registration is now open!

This event will bring together a selected group of international experts at the intersection of immunotoxicology, systems biology, and regulatory science.
The workshop aims to explore how the Adverse Outcome Pathway (AOP) framework can enhance our understanding and prediction of inflammation-driven toxicities, particularly those related to immune system dysregulation.

Key highlights include:

  • Keynote presentations and focused scientific sessions
  • Interactive breakout discussions
  • Addressing current knowledge gaps in inflammation-related AOPs
  • Integration of novel in vitro approaches (NAMs) into predictive frameworks

We also look forward to contributions from our imSAVAR project on complex immune responses and synergies with related initiatives like T2EVOLVE.
A significant outcome will be the initiation of a jointly co-authored paper, showcasing advances, methodologies, and collaborative opportunities in the AOP space.

Download the full Programme here: Programme – ImSAVAR Workshop: Mapping Inflammation – Towards Predictive AOPs for Immune-Related Adverse Outcomes

PROGRAMME

08:30 Registration & Coffee
09:00 Welcome & Introduction
Katherina Sewald (Fraunhofer ITEM) & Laure-Alix Clerbaux (UCLouvain)

  • Workshop goals, agenda & expected outcomes
09:15 Session 1: AOPs as Strategic Tools for Inflammatory Responses: Regulatory Point of View
Chair: Laure-Alix Clerbaux (UCLouvain)

  • “The AOP Framework: Strategic Tools for Elucidating Biological Mechanisms”- Clemens Wittwehr (JRC) (25 min)
  • “OECD’s Experience in AOP and NAMs Development: Regulatory Insights and Case Studies” – Magdalini Sachana (OECD) (25 min)
  • Q&A and short discussion (10 min)
10:15 Session 2: Inflammatory AOPs Used for Risk Assessment of Chemicals
Chair: Katherina Sewald (Fraunhofer ITEM)

  • “Development of Immune-Related AOPs in PARC” – Birgitte Lindeman (Norwegian Institute of Public Health) (25 min)
  • “Integrative Analysis of Silica-Associated Disease Mechanisms in the EXIMIOUS Project” – Manosij Ghosh (KULeuven) (25 min)
  • “Nanoparticle-Induced Inflammation: Linking Exposure to Chronic Outcomes via AOPs” – Sabina Halappanavar (Health Canada) (25 min)
  • Q&A and short discussion (15 min)
11:45 Lunch Break
12:30 Session 3: Mapping inflammation with AOPs and NAMs for Biomedical Stressors – Part 1
Chair: Hannah Morgan (Novartis)

  • “Leveraging inflammatory AOPs in pandemic times: Insights from the CIAO COVID-19  Initiative”- Laure-Alix Clerbaux (UCLouvain) (25 min)
  • “Developing In Vitro Models for Immune-Related Adverse Outcome Prediction: An Introduction to imSAVAR”- Katherina Sewald (Fraunhofer ITEM) (15 min)
  • “From Mechanism to Prediction: Integrating NAMs with AOPs in Complex Immunopathologies”- Hannah Morgan (Novartis) and Miriam Alb (University of Wurzburg) (25 min)
13:35 Coffee Break
13:45 Session 3: Mapping inflammation with AOPs and NAMs for Biomedical Stressors – Part 2
Chair: Hannah Morgan (Novartis)

  • An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies – Marek Ostaszewski (University of Luxembourg) (25 min)
  • “Synergies between Immunotherapy Safety and AOP/NAM Development”- Scott Wagers (BioSci) (25 min)
  • Q&A and short discussion (25 min)
15:00 Breakout Session: Towards a Joint Perspectives Workshop Paper
Facilitated small groups work on:

  • Mapping inflammation-related AOPs
  • Mechanistic gaps & challenges
  • NAMs integration
  • Regulatory applicability
15:45 Wrap-Up & Next Step
Katherina Sewald (Fraunhofer ITEM) & Laure-Alix Clerbaux (UCLouvain)

  • Summary from breakout groups
  • Paper coordination
  • Outlook for future collaboration
16:00 End

 

Please note that spaces are limited. We encourage you to register promptly to secure your spot.