Scientific articles

T. I. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudecek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Publication: Advanced Drug Delivery Reviews, Volume 173, Pages 281-305, 2021.
DOI: 10.1016/j.addr.2021.03.015  

B. Seliger, K. Reiche, C. Massa, S. Fricke, G. Schmiedeknecht, F. Horn, C. Blumert, M. Alb, M.l Hudecek, U. Koehl
Necessity for next-generation quality assessment of CAR T cell manufacturing and advanced therapy guidance
Publication: Cell & Gene Therapy Insights, Volume 1(3), Pages 163–168, 2020.
DOI: 10.18609/ioi.2020.019  

T. Kirsten, F. A. Meineke, H. Loeffler-Wirth, C. Beger, A. Uciteli, S. Stäubert, M. Löbe, R. Hänsel, F. G. Rauscher, J. Schuster, T. Peschel, H. Herre, J. Wagner, S. Zachariae, C. Engel, M. Scholz, E. Rahm, H. Binder, M. Loeffler
The Leipzig Health Atlas – An open platform to present, archive and share bio-medical data, analyses and models online
Publication: Methods of Information in Medicine, Volume 61, 2022.
DOI: 10.1055/a-1914-1985  

H. Loeffler-Wirth, M. Rade, A. Arakelyan, M. Kreuz, M. Loeffler, U. Koehl, K. Reiche, H. Binder
Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying
Publication: Frontiers in Immunology, 2022.
DOI: 10.3389/fimmu.2022.994885  

Z. Zhao, M. Zucknick, T. Aittokallio
EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets
Publication: Bioinformatics Advances, 2022.
DOI: 10.1093/bioadv/vbac073  

H. Lê; C. Ponté; J. Desforges; G. Hua; Y. Idoux-Gillet; V. Lindner; A. Olland; P.-E. Falcoz; C. Zaupa; E. Quéméneur; J.-M. Balloul; N. Jessel
Vascularized patient-derived tumoroids supplemented with immune cells to predict response towards treatment for lung cancer patients
Publication: iScience, 2023. 
DOI: 10.21203/rs.3.rs-2560741/v1  

B. Glatte; K. Wenk; A. Grahnert; M. Friedrich; M. Merz; V. Vucinic; L. Fischer; K. Reiche; M. Alb; M. Hudecek; P. Franz; S. Fricke; U. Platzbecker; U. Koehl; U. Sack; A. Boldt; S. Hauschildt; R. Weiss
Teclistamab impairs detection of BCMA CAR-T cells
Publication: Blood Advances, 2023. 
DOI: 10.1182/bloodadvances.2023009714  

X. Zhou; L. Rasche; K. M. Kortüm; S. Danhof; M. Hudecek; H. Einsele
Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.
Publication: Frontiers in Immunology, 2020. 
DOI: 10.3389/fimmu.2020.620312  

Z. Abdulrahman; S. J. Santegoets; G. Sturm; P. Charoentong; M. E. Ijsselsteijn; A. Somarakis; T. Höllt; F. Finotello; Z. Trajanoski; S. L. van Egmond; D. A. M. Mustafa; M. J. P. Welters; N. F. C. C. de Miranda; S. H. van der Burg
Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival
Publication: Society for Immunotherapy of Cancer, 2022. 
DOI: 10.1136/jitc-2021-004346  

M. Rade; S. Böhlen; V. Neuhaus; D. Löffler; C. Blumert; M. Merz; U. Köhl; S. Dehmel; K. Sewand; K. Reiche
A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation
Publication: Genome Biology, 2023.
DOI: 10.1186/s13059-023-03120-7

C. Sommer; S. Jacob; T. Bargmann; M. Shoaib; B. Alshaikhdeeb; V. P. Satagopam; S. Dehmel; V. Neuhaus; A. Braun; K. Sewald
Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology
Publication: Journal of Clinical Immunology, 2024.
DOI:  10.1016/j.clim.2024.110288

C. Sommer; J. Cohen; S. Dehmel; V. Neuhaus;  D. Schaudien; A. Braun; K. Sewald; M. Rosenblum
Interleukin-2-induced skin inflammation
Publication: European Journal of Immunology, 2024.
DOI: 10.1002/eji.202350580

T. I. Maulana; C. Teufel; M. Cipriano; J. Roosz; L. Lazarevski; F. E. van den Hil; L. Scheller;  V. Orlova; A. Koch; M. Hudecek; M. Alb; P. Loskill
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells
Publication: Cell Stem Cell, 2024.
DOI: 10.1016/j.stem.2024.04.018

L. A. Roser; S. Luckhardt; N. Ziegler; D. Thomas; P. V. Wagner; G. Damm; A. Scheffschick; P. Hewitt; M. J. Parnham; S. Schiffmann
Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin
Publication: Frontiers in Immunology, 2023. 
DOI: 10.3389/fimmu.2023.1275368

M. Schmidt; S. Avagyan; K. Reiche; H. Binder; H. Loeffler-Wirth
A Spatial Transcriptomics Browser for Discovering Gene Expression Landscapes across Microscopic Tissue Sections
Publication: Current Issues in Molecular Biology, 2024.
DOI: 10.3390/cimb46050284