Scientific articles
2024
Neuhaus, V., Clerbaux, L. A., & Sewald, K.
An overview of immune safety avatar: mimicking the effects of immunomodulatory therapies on the immune system
Publication: Journal of Immunotoxicology, 21(sup1), S1–S4, 2024.
DOI: 10.1080/1547691X.2024.2354213
Mazein, A., Shoaib, M., Alb, M., Sakellariou, C., Sommer, C., Sewald, K., … Gu, W.
Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways
Publication: Journal of Immunotoxicology, 21(sup1), S5–S12, 2024.
Link: 10.1080/1547691X.2024.2345154
Alb, M., Reiche, K., Rade, M., Sewald, K., Loskill, P., Cipriano, M., … Hudecek, M.
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept
Publication: Journal of Immunotoxicology, 21(sup1), S13–S28, 2024.
Link: 10.1080/1547691X.2024.2345158
Dinh-Le, T., Escobar, J., Poisson, L., Adkins, K., Jornet Culubret, M., Scheller, L., … Luna, E.
Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay
Publication: Journal of Immunotoxicology, 21(sup1), S29–S37, 2024.
Link: 10.1080/1547691X.2024.2378729
Roser, L. A., Sommer, C., Ortega Iannazzo, S., Sakellariou, C., Waibler, Z., & Gogesch, P.
Revival of recombinant IL-2 therapy – approaches from the past until today
Publication: Journal of Immunotoxicology, 21(sup1), S38–S47, 2024.
Link: 10.1080/1547691X.2024.2335219
Sommer, C., Neuhaus, V., Gogesch, P., Flandre, T., Dehmel, S., & Sewald, K.
Type 2 responses determine skin rash during recombinant interleukin-2 therapy
Publication: Journal of Immunotoxicology, 21(sup1), S48–S59, 2024.
Link: 10.1080/1547691X.2024.2343359
Roser, L. A., Sakellariou, C., Lindstedt, M., Neuhaus, V., Dehmel, S., Sommer, C., … Schiffmann, S.
IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept
Publication: Journal of Immunotoxicology, 21(sup1), S60–S78, 2024.
Link: 10.1080/1547691X.2024.2332177
Gogesch, P., Ortega Iannazzo, S., Zimmermann, T., Villenave, R., Sewald, K., & Waibler, Z.
Analyzing IL-2-induced vascular leakage with an irAOP as tool
Publication: Journal of Immunotoxicology, 21(sup1), S79–S88, 2024.
Link: 10.1080/1547691X.2024.2369123
Sakellariou, C., Roser, L. A., Schiffmann, S., & Lindstedt, M.
Fine tuning of the innate and adaptive immune responses by Interleukin-2
Publication: Journal of Immunotoxicology, 21(sup1), S89–S95, 2024.
Link: 10.1080/1547691X.2024.2332175
Braun, A., & Dehmel, S.
Using irAOP for non-clinical safety evaluation of biotechnology-derived pharmaceuticals and ATMPs: a paradigm shift into a systematic and holistic framework
Publication: Journal of Immunotoxicology, 21(sup1), S96–S98, 2024.
Link: 10.1080/1547691X.2024.2390920
C. Sommer; S. Jacob; T. Bargmann; M. Shoaib; B. Alshaikhdeeb; V. P. Satagopam; S. Dehmel; V. Neuhaus; A. Braun; K. Sewald
Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology
Publication: Journal of Clinical Immunology, 2024.
DOI: 10.1016/j.clim.2024.110288
T. I. Maulana; C. Teufel; M. Cipriano; J. Roosz; L. Lazarevski; F. E. van den Hil; L. Scheller; V. Orlova; A. Koch; M. Hudecek; M. Alb; P. Loskill
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells
Publication: Cell Stem Cell, 2024.
DOI: 10.1016/j.stem.2024.04.018
H. Lê, J. Deforges, P. Cutolo, A. Lamarque, G. Hua, V. Lindner, S. Jain, J-M. Balloul, N. Benkirane-Jessel, E. Quéméneur
Patient-derived tumoroids and proteomic signatures: tools for early drug discovery
Publication: Frontiers in Immunology, 2024.
DOI: 10.3389/fimmu.2024.1379613
Z. Zhao; J. Zobolas; M. Zucknick; T. Aittokallio
Tutorial on survival modeling with applications to omics data
Publication: Bioinformatics, Volume 40, Issue 3, March 2024.
DOI: 10.1093/bioinformatics/btae132
C. Sommer; J. Cohen; S. Dehmel; V. Neuhaus; D. Schaudien; A. Braun; K. Sewald; M. Rosenblum
Interleukin-2-induced skin inflammation
Publication: European Journal of Immunology, 2024.
DOI: 10.1002/eji.202350580
2023
C.Plattner, G. Lamberti, P. Blattmann, A. Kirchmair, D. Rieder, Z. Loncova, G. Sturm, S. Scheidl, M. Ijsselsteijn, G.s Fotakis, A. Noureen, R. Lisandrelli, N. Böck, N. Nemati, A. Krogsdam, S. Daum, F. Finotello, A. Somarakis, A. Schäfer, D. Wilflingseder, M. Gonzalez Acera, D. Öfner, L. A. Huber, H. Clevers, Christoph Becker, Henner F. Farin, Florian R. Greten, R. Aebersold, N. F.C.C. de Miranda, Z. Trajanoski
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
Publication: iScience, Volume 26, Issue 12, 2023.
DOI: 10.1016/j.isci.2023.108399
L. A. Roser; S. Luckhardt; N. Ziegler; D. Thomas; P. V. Wagner; G. Damm; A. Scheffschick; P. Hewitt; M. J. Parnham; S. Schiffmann
Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin
Publication: Frontiers in Immunology, 2023.
DOI: 10.3389/fimmu.2023.1275368
H. Lê, J. Deforges, G. Hua, Y. Idoux-Gillet, C. Ponté, V. Lindner, A. Olland, P.-E. Falcoz, C. Zaupa, S. Jain, E. Quéméneur,
N. Benkirane-Jessel, J.-M. Balloul
In vitro vascularized immunocompetent patient-derived model to test cancer therapies
Publication: iScience, Volume 26, Issue 10, 2023.
DOI: 10.1016/j.isci.2023.108094
B. Glatte; K. Wenk; A. Grahnert; M. Friedrich; M. Merz; V. Vucinic; L. Fischer; K. Reiche; M. Alb; M. Hudecek; P. Franz; S. Fricke; U. Platzbecker; U. Koehl; U. Sack; A. Boldt; S. Hauschildt; R. Weiss
Teclistamab impairs detection of BCMA CAR-T cells
Publication: Blood Advances, 2023.
DOI: 10.1182/bloodadvances.2023009714
T. I. Maulana; C. Teufel; M. Cipriano; L. Lazarevski; F. E. van den Hil; V. Orlova; A. Koch; M. Alb; M. Hudecek; P. Loskill
Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy
Preprint:
DOI: 10.1101/2023.07.13.548856
S. Mojtahed Poor, M. Henke, T. Ulshöfer, M. Köhm, F. Behrens, H. Burkhardt, S. Schiffmann
The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate
Publication: Rheumatology, Volume 62, Issue 12, December 2023.
DOI: 10.1093/rheumatology/kead177
A. Mazein, M. Shoaib, M. Alb, C. Sakellariou, C. Sommer, K. Sewald, K. Reiche, P. Gogesch, L. A Roser, S. Ortega Iannazzo, S. Sheth, S. Schiffmann, Z. Waibler, V. Neuhaus, S. Dehmel, V. Satagopam, R. Schneider, imSAVAR Consortium, M. Ostaszewski, W. Gu
Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways
Preprint:
H. Lê; C. Ponté; J. Desforges; G. Hua; Y. Idoux-Gillet; V. Lindner; A. Olland; P.-E. Falcoz; C. Zaupa; E. Quéméneur; J.-M. Balloul; N. Jessel
Vascularized patient-derived tumoroids supplemented with immune cells to predict response towards treatment for lung cancer patients
Publication: iScience, Volume 26, Issue 10, 2023.
DOI: 10.21203/rs.3.rs-2560741/v1
2022
T. Kirsten, F. A. Meineke, H. Loeffler-Wirth, C. Beger, A. Uciteli, S. Stäubert, M. Löbe, R. Hänsel, F. G. Rauscher, J. Schuster, T. Peschel, H. Herre, J. Wagner, S. Zachariae, C. Engel, M. Scholz, E. Rahm, H. Binder, M. Loeffler
The Leipzig Health Atlas – An open platform to present, archive and share bio-medical data, analyses and models online
Publication: Methods of Information in Medicine, Volume 61, 2022.
DOI: 10.1055/a-1914-1985
H. Loeffler-Wirth, M. Rade, A. Arakelyan, M. Kreuz, M. Loeffler, U. Koehl, K. Reiche, H. Binder
Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying
Publication: Frontiers in Immunology, 2022.
DOI: 10.3389/fimmu.2022.994885
Z. Zhao, M. Zucknick, T. Aittokallio
EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets
Publication: Bioinformatics Advances, 2022.
DOI: 10.1093/bioadv/vbac073
Z. Zhao, S. Wang, M. Zucknick, T. Aittokallio
Tissue-specific identification of multi-omics features for pan-cancer drug response prediction
Publication: iScience, Volume 25, Issue 8, 2022.
DOI: 10.1016/j.isci.2022.104767
Z. Abdulrahman; S. J. Santegoets; G. Sturm; P. Charoentong; M. E. Ijsselsteijn; A. Somarakis; T. Höllt; F. Finotello; Z. Trajanoski; S. L. van Egmond; D. A. M. Mustafa; M. J. P. Welters; N. F. C. C. de Miranda; S. H. van der Burg
Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival
Publication: Society for Immunotherapy of Cancer, 2022.
DOI: 10.1136/jitc-2021-004346
2021
Prommersberger, S., Reiser, M., Beckmann, J. et al.
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.
Publication: Gene Ther 28, 560–571 (2021).
DOI: 10.1038/s41434-021-00254-w
T. I. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudecek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Publication: Advanced Drug Delivery Reviews, Volume 173, Pages 281-305, 2021.
DOI: 10.1016/j.addr.2021.03.015
E. G.B.M. Bossink, A. R. Vollertsen, L. Segerink, A. van der Meer, M. Odijk
Automated medium recirculation using macro valves for high flow rates in an endothelial cell culture chip
Publication in Conference Proceeding: Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Link to publication
E. G.B.M. Bossink, A. R. Vollertsen, L. P. Hagen , A. van der Meer, L. Segerink, M. Odijk
Multiplexed Organ-on-Chips with integrated macro valves for automated cell culture
Publication in Conference Proceeding: Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Link to publication
2020
X. Zhou; L. Rasche; K. M. Kortüm; S. Danhof; M. Hudecek; H. Einsele
Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.
Publication: Frontiers in Immunology, 2020.
DOI: 10.3389/fimmu.2020.620312
B. Seliger, K. Reiche, C. Massa, S. Fricke, G. Schmiedeknecht, F. Horn, C. Blumert, M. Alb, M.l Hudecek, U. Koehl
Necessity for next-generation quality assessment of CAR T cell manufacturing and advanced therapy guidance
Publication: Cell & Gene Therapy Insights, Volume 1(3), Pages 163–168, 2020.
DOI: 10.18609/ioi.2020.019