Immune Safety Avatar

Nonclinical mimicking of the immune system effects of immunomodulatory therapies

The imSAVAR Vision

The vision of Immune Safety Avatar (imSAVAR) is to develop a platform for the integrated nonclinical assessments of safety and efficacy of immunomodulatory therapeutic modalities.

The imSAVAR project is a pioneering initiative funded by the Innovative Medicines Initiative (IMI), dedicated to enhancing the nonclinical safety assessment of immunotherapies.

The primary objective is the creation of a platform to significantly improve the prediction of potential side effects and thereby the safety and efficacy of immunomodulatory therapeutics. We want to achieve that by developing fit-for-purpose nonclinical models with high transferability from laboratory settings to real-world applications.

As partners from the private sector, pharma, regulators, and technology providers closely collaborate in this consortium, imSAVAR will benefit the field of immune safety evaluation. Through these concerted efforts, imSAVAR aims to positively impact the field of immune safety evaluation and pave the way for the future of immunomodulatory therapeutics.

 

Ulrike Köhl - imSAVAR Coordinator

“If we really want to move forward with these modern immunomodulatory therapies we need much more research on predictive markers and predictive models. With the imSAVAR project we aim to tackle the challenge of a better understanding of the complexity of the human immune system.​”

Ulrike Köhl / Coordinator

Jonathan Moggs - imSAVAR Coordinator

“The imSAVAR team plans to characterise a range of innovative human-relevant models and biomarkers to enhance translational safety assessment of immunomodulatory therapeutics and ultimately lead to the development of safer efficacious medicines for patients.​”

Jonathan Moggs / Coordinator

Learn more about the imSAVAR project

Concept

Read more about our challenges, approach, objectives and the impact we want to make.

Consortium

The interdisciplinary imSAVAR consortium consists of 28 international partners from 11 nations.

Forum

Engage in lively discussions and help built up a strong imSAVAR stakeholder community.

Publications

Have a look at our imSAVAR scientific articles and project publications.

Learn more about the imSAVAR project

Concept

Read more about our challenges, approach, objectives and the impact we want to make.

Consortium

The interdisciplinary imSAVAR consortium consists of 28 international partners from 11 nations.

Publications

Have a look at our imSAVAR scientific articles and project publications.

Latest News

Valentin Wegner

Student Portrait #5: Valentin Wegner

Numerous dedicated researchers are actively contributing to imSAVAR, enhancing the project’s success. We’re pleased to showcase a recent profile featuring Valentin Wegner and his impactful work on an organ-on-chip

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1st imSAVAR study-a-thon

The first imSAVAR study-a-thon took place from 12 to 15 June 2023 at Fraunhofer IZI in Leipzig, Germany. 17 consortium members from ULEI, UNILU, UKW, IZI, ITEM, NVS, LABCORP,

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